Jacqueline Brockhurst, VMD, PHD, DACLAM
Education
BS Biology, Stanford University, Stanford CA, 2014
VMD, University of Pennsylvania School of Veterinary Medicine, Pennsylvania, PA, 2018
Residency, Laboratory Animal Medicine, Johns Hopkins University, Baltimore MD, 2022
PhD, Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, 2024
Diplomate, American College of Laboratory Animal Medicine (DACLAM), 2022
About
Dr. Brockhurst is the Director of Animal Modeling Services within Research Animal Resources and an Assistant Professor in the Department of Molecular and Comparative Pathobiology at the Johns Hopkins University School of Medicine. Within this role, she provides consultation on model development, experimental design, and protocol writing, along with technical and procedural support for researchers. She also oversees the JHU High Containment Facility animal care program. As a veterinarian-scientist, her overarching objectives are to develop and refine animal research to improve translatability, with a particular focus on infectious disease research. She is passionate about teaching and serving as a mentor to numerous students and veterinary residents.
Dr. Brockhurst obtained her PhD under the mentorship of Diane Griffin, MD, PhD, in 2024. Her research focuses on the pathogenesis and local immune response to measles virus (MeV) infection of airway epithelium, using both a macaque model and primary differentiated respiratory epithelial cells, with the goal of identifying factors that contribute to MeV transmission and protection from disease. She has contributed to studies examining the effects of remdesivir on measles treatment and prevention, the immune response to measles-mumps-rubella (MMR) and novel vaccine candidates, and the acute and long-term immune responses and MeV RNA persistence following wild-type versus live-attenuated MeV challenge. She also works collaboratively with other investigators to execute vaccine, novel therapeutic, and immunology studies in animal models of SARS-CoV-2, Shigella infection, tuberculosis, and simian immunodeficiency virus.