Lisa M. Mangus, DVM, PhD, DACVP
Miller Research Building, Suite 853
Ohio State Univ College of Veterinary Medicine, Columbus, OH
Johns Hopkins University School of Medicine
Lisa Mangus is a board-certified veterinary anatomic pathologist and Instructor in the Department of Molecular and Comparative Pathobiology. She completed her doctorate of veterinary medicine at the Ohio State University College of Veterinary Medicine in 2009, after which she did an internship in small animal surgery and medicine at the VCA Veterinary Referral Associates in Gaithersburg, MD. Dr. Mangus did her comparative anatomic pathology residency in the Department of Molecular and Comparative Pathobiology (MCP) at Johns Hopkins University and joined the American College of Veterinary Pathologists as a diplomate in 2015. Concurrently with her anatomic pathology training, Dr. Mangus studied neuroimmunology and HIV-associated sensory neuropathy in laboratory of Dr. Joseph Mankowski as a graduate student in the Cellular and Molecular Medicine graduate training program. She finished her PhD in 2016, and shortly after joined MCP as an Instructor.
As a comparative pathologist and instructor at Johns Hopkins School of Medicine, Dr. Mangus' academic and research interests focus primarily on neuroimmunology and the pathogenesis of HIV-associated sensory neuropathy (HIV-SN). Since 2012, she have been working in the Retrovirus Laboratory where she utilizes a unique SIV-infected pigtailed macaque model of HIV-associated neurologic disease. In this time, Dr. Mangus have participated in numerous macaque necropsies and have performed comprehensive histopathologic analyses for several SIV studies, including investigations using experimental treatments. Dr. Mangus has extensive experience in advanced molecular and microscopic techniques such as quantitative real-time PCR, immunohistochemistry, histopathologic image analysis, stereology, and confocal microscopy, all of which can be employed to complement and enhance traditional pathologic analyses.
In addition to these research interests, Dr. Mangus has a special interest in exotic and aquatic veterinary pathology. In the Department of Molecular and Comparative Pathobiology, she serves as the exotics and aquatics veterinary pathology liaison for the National Aquarium in Baltimore and the Baltimore Zoo.
- Mangus LM, Dorsey JL, Weinberg RL, Ebenezer GJ, Hauer P, Laast VA, Mankowski JL. Tracking Epidermal Nerve Fiber Changes in Asian Macaques: Tools and Techniques for Quantitative Assessment.. Toxicol Pathol. 2016 Aug;44(6):904-12.
- Dorsey JL, Mangus LM, Hauer P, Ebenezer GJ, Queen SE, Laast VA, Adams RJ, Mankowski JL. Persistent Peripheral Nervous System Damage in Simian Immunodeficiency Virus-Infected Macaques Receiving Antiretroviral Therapy.. J Neuropathol Exp Neurol. 2015 Nov;74(11):1053-60.
- Mangus LM, Dorsey JL, Laast VA, Hauer P, Queen SE, Adams RJ, McArthur JC, Mankowski JL. Neuroinflammation and virus replication in the spinal cord of simian immunodeficiency virus-infected macaques.. J Neuropathol Exp Neurol. 2015 Jan;74(1):38-47.
- Dorsey JL, Mangus LM, Oakley JD, Beck SE, Kelly KM, Queen SE, Metcalf Pate KA, Adams RJ, Marfurt CF, Mankowski JL. Loss of corneal sensory nerve fibers in SIV-infected macaques: an alternate approach to investigate HIV-induced PNS damage.. Am J Pathol. 2014 Jun;184(6):1652-9.
- Mangus LM, Dorsey JL, Laast VA, Ringkamp M, Ebenezer GJ, Hauer P, Mankowski JL.Unraveling the pathogenesis of HIV peripheral neuropathy: insights from a simian immunodeficiency virus macaque model.. ILAR J. 2014;54(3):296-303.