Chris Zink, DVM, PhD, DACVP, DACVSMR
Miller Research Building, Room 835
University of Guelph, Ontario Veterinary College
Johns Hopkins University, Baltimore MD
Dr. Zink has been studying the pathogenesis of lentiviral infections for over 30 years. Drs. Zink, Clements, and Mankowski developed a highly reproducible, rapid SIV/macaque model of HIV that faithfully reproduces all the key features of HIV infection and cART therapy, as well as residual CNS inflammation in individuals on cART therapy. This model is ideal for rigorous testing of novel drugs for amelioration of residual/persistent CNS manifestations and of drugs to activate virus with the goal of virus eradication. Dr. Zink has published extensively on the pathogenic mechanisms of HIV/SIV as well as the host defenses and responses to viral infection using this and other animal models as well as human blood/CSF samples and tissues. She has served on numerous study sections, and held numerous leadership positions both at Johns Hopkins and nationally, and has an international reputation in the field of HIV/SIV. Dr. Zink currently plays a clinical and teaching role for graduate students and postdoctoral fellows in the Department of Molecular and Comparative Pathobiology and assists in the preparation and review of grant applications and manuscripts
1. Beck SE, Kelly KM, Queen SE, Adams RJ, Zink MC, Tarwater PM, Mankowski JL.Macaque species susceptibility to simian immunodeficiency virus: increased incidence of SIV central nervous system disease in pigtailed macaques versus rhesus macaques. J Neurovirol. 2015 Apr;21(2):148-58
2. Meulendyke KA, Queen SE, Engle EL, Shirk EN, Liu J, Steiner JP, Nath A, Tarwater PM, Graham DR, Mankowski JL, Zink MC. Combination fluconazole/paroxetine treatment is neuroprotective despite ongoing neuroinflammation and viral replication in an SIV model of HIV neurological disease. J Neurovirol. 2014 Dec;20(6):591-602.
3. Meulendyke KA, Croteau JD, Zink MC. HIV life cycle, innate immunity and autophagy in the central nervous system. Curr Opin HIV AIDS. 2014 Nov;9(6):565-71.
4. Meulendyke KA, Ubaida-Mohien C, Drewes JL, Liao Z, Gama L, Witwer KW, Graham DR, Zink MC. Elevated brain monoamine oxidase activity in SIV- and HIV-associated neurological disease. J Infect Dis. 2014 Sep 15;210(6):904-12.
5. Drewes JL, Szeto GL, Engle EL, Liao Z, Shearer GM, Zink MC, Graham DR. Attenuation of pathogenic immune responses during infection with human and simian immunodeficiency virus (HIV/SIV) by the tetracycline derivative minocycline. PLoS One. 2014 Apr 14;9(4):e94375.